Status:
WITHDRAWN
Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q4
Lead Sponsor:
Vanderbilt University
Conditions:
Type 1 Diabetes
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Epinephrine is one of the important hormones in the defense of hypoglycemia. We will test the hypothesis that antecedent hypoglycemia will blunt the metabolic, neuroendocrine and cardiovascular effect...
Detailed Description
When a person had previously experienced bouts of low blood sugar, or hypoglycemia, his or her counterregulatory responses to hypoglycemia would be weakened. This is especially true and important for ...
Eligibility Criteria
Inclusion
- 28 (14 males, 14 females) conventionally treated Type 1 diabetic patients with HA1C \> 8.5%
- 28 (14 males, 14 females) intensively treated Type 1 diabetic patients with HA1C \< 7%
- 28 (14 males, 14 females) non-diabetic controls
- Age 18-45 yr.
- Had diabetes for 2-15 years if diabetic subject
- No clinical evidence of diabetic tissue complications, no cardiovascular disease
- Body mass index 21-27kg · m-2
- Normal bedside autonomic function
- Normal results of routine blood test to screen for hepatic, renal, and hematological abnormalities
- Female volunteers of childbearing potential: negative HCG pregnancy test
Exclusion
- Prior history of poor health: any current or prior disease condition that alters carbohydrate metabolism and prior cardiac events and/or evidence for cardiac disease
- Hemoglobin of less than 12 g/dl
- Abnormal results following screening tests
- Pregnancy
- Subjects unable to give voluntary informed consent
- Subjects with a recent medical illness
- Subjects with known liver or kidney disease
- Subjects taking steroids
- Subjects taking beta blockers
- Subjects on anticoagulant drugs, anemic, or with known bleeding diseases
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00608816
Last Update
December 11 2014
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