Status:
COMPLETED
Treatment With Copper in Patients With Mild Alzheimer´s Dementia
Lead Sponsor:
University Hospital, Saarland
Collaborating Sponsors:
University of Goettingen, Section Neurobiology (Head: Prof. Dr. T. Bayer), Germany
Conditions:
Alzheimer´s Disease
Eligibility:
All Genders
50-80 years
Phase:
PHASE2
Brief Summary
The efficacy of 8 mg of copper daily regarding cognitive function, content of beta amyloid protein in the CSF and volumetric changes in the brain will be examined in a first double-blind, placebo-cont...
Eligibility Criteria
Inclusion
- male or female patients
- between 50 and 80 years
- criteria of mild dementia
- probable Alzheimer´s dementia according to NINCDS-ADRDA criteria
- given written informed consent
- having a relative who can fill out questionnaire; caregiver consent
- free of serious and unstable somatic illness
Exclusion
- unable to give informed consent
- unable to take cholinesterase inhibitors
- unapproved medication
- moderate to severe Alzheimer´s disease
- dementia of other etiology
- history of alcohol, drug or medication abuse
- other psychiatric disorder, e. g. schizophrenia
- known copper and zinc storage disease
- known copper and zinc intolerance
- vegans
- known severe allergies or intolerances
- insufficient knowledge of the German language
- female patients of childbearing potential, pregnant or nursing patients
- participation in a clinical trial within the past 30 days before onset of this study
- severe somatic diseases and high mortality rate AST, ALT, GGT, GLDH, AP or bilirubin being a two-fold above the normal range
Key Trial Info
Start Date :
March 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT00608946
Start Date
March 1 2004
Last Update
February 6 2008
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.