Status:
COMPLETED
Genomics of Chronic Renal Allograft Rejection (The GoCAR Study)
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Kidney Transplantation
Eligibility:
All Genders
18-75 years
Brief Summary
Doctors have had success preventing certain types of kidney transplant rejection by suppressing the immune system. However, an individual's genetic make-up and the strength of an immune response to a ...
Detailed Description
New immunosuppressive drugs have improved short-term transplant survival but have not affected long-term transplant survival. Rejection is caused by both immunological and non-immunological factors fr...
Eligibility Criteria
Inclusion
- Kidney transplant candidates from living or deceased donors
- Male or female, ages 18-75 years
- Subject must be able to understand and provide written informed consent
- Living Donors - Recipient also consents to participate in the study
Exclusion
- Presence of Donor Specific Antibodies in living donor recipients prior to transplantation OR positive cross match according to site-specific technique in cadaveric donor recipients
- Recipients of multiple organ transplants, with the exception of kidney/pancreas transplants.
- Inability or unwillingness to comply with the study protocol.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
588 Patients enrolled
Trial Details
Trial ID
NCT00611702
Start Date
June 1 2008
End Date
July 1 2013
Last Update
May 14 2015
Active Locations (5)
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1
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
2
University of Michigan
Ann Arbor, Michigan, United States, 48109
3
Mt. Sinai School of Medicine
New York, New York, United States, 10029
4
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53706