Status:
TERMINATED
The Use of Propranolol to Block Memory Reconsolidation in PTSD
Lead Sponsor:
Wayne State University
Collaborating Sponsors:
John D. Dingell VA Medical Center
New York University
Conditions:
Posttraumatic Stress Disorders
Eligibility:
FEMALE
18-45 years
Phase:
PHASE2
Brief Summary
The purpose of this investigation is to see if propranolol will reduce the psychophysiological hyperactivation associated with memories of combat stress in Veterans with Posttraumatic Stress Disorder.
Detailed Description
The goal of this translational research project is to generate a pilot sample of data from an investigation of a novel therapeutic approach to post traumatic stress disorder (PTSD). Current treatments...
Eligibility Criteria
Inclusion
- Participants will meet the clinical criteria of PTSD (DSM IVTR) secondary to combat exposure.
Exclusion
- Current illicit substance use or alcohol consumption, as determined by urine toxicology and alcohol breath test.
- Any diagnosis of current comorbid psychotic disorders, bipolar disorder, or illicit substance or alcohol abuse or dependence.
- Any current prescription medication usage or supplement (dietary or herbal) usage that is contraindicated with propranolol.
- Active enrollment into any psychiatric or psychological treatment.
- Any condition that contraindicates the use of propranolol, such as:
- history of bronchial asthma.
- heart block.
- sinus bradycardia.
- congestive heart failure.
- insulin-dependent diabetes.
- initial systolic blood pressure \< 100 mmHg.
- Hyperthyroidism.
- Thyroid disease.
- Renal or liver impairment.
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT00611871
Start Date
September 1 2007
End Date
September 1 2015
Last Update
November 1 2016
Active Locations (1)
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1
John D Dingell VA Hospital
Detroit, Michigan, United States, 48201