Status:
COMPLETED
N-acetylcysteine and NMDA Antagonist Interactions
Lead Sponsor:
Yale University
Conditions:
Cognitive Dysfunction
Eligibility:
All Genders
21-45 years
Phase:
PHASE1
PHASE2
Brief Summary
This study tests the hypothesis that extrasynaptic mechanisms are critically linked with cognitive effects of NMDA antagonism as evidenced by event-related potentials (ERPs) in healthy humans.
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Ages of 21-45 years from all ethnic backgrounds.
- Male or female.
- Written informed consent.
- Exclusion criteria
- DSM-IV diagnosis for a psychotic, depressive or anxiety disorder.
- A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox, Urine pregnancy test) .
- History of severe allergies or multiple adverse drug reactions.
- Any medication that in the opinion of the PI could interfere with either the safety of the study and/or the outcome measures.
- Any other conditions which in the opinion of the investigator would preclude participation in the study.
- History of major psychiatric disorder in first degree relatives.
- Current substance abuse/dependency determined by urine toxicology.
- Current treatment with medications with psychotropic effects.
- Treatment with benzodiazepines within one week prior to testing.
- Current pregnancy, unsatisfactory birth control method report for females.
- Education \< 10th grade.
- IQ \< 70, MR as determined by Wechsler Abbreviated Scale of Intelligence.
- Non-English speaking.
Exclusion
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00611897
Start Date
January 1 2006
End Date
February 1 2011
Last Update
May 8 2015
Active Locations (1)
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1
VHA Connecticut
West Haven, Connecticut, United States, 06516