Status:
COMPLETED
The Effect of Sertindole on Sensory Gating and Cognition in Healthy Volunteers
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Psychiatric University Hospital, Zurich
H. Lundbeck A/S
Conditions:
Healthy
Eligibility:
MALE
18-40 years
Phase:
NA
Brief Summary
This study aims to further validate and extend our previous findings insofar that the effect of the atypical antipsychotic and mixed 5-HT2/D2 antagonist sertindole on sensorimotor gating processes and...
Eligibility Criteria
Inclusion
- Age: 18-40
- Gender: male
Exclusion
- Axis I Disorders: lifetime DSM IV diagnosis according to DIA-X of alcohol or illicit drug dependence. No life-time DSM IV diagnosis according to DIA-X of a major affective, psychotic, anxiety disorder, eating-disorder as defined above.
- Axis II Disorders: lifetime DSM IV diagnosis of personality disorder according to SCID-II.
- Family history: lifetime history of 1st degree relative (parents and siblings) of a major affective, psychotic, or anxiety disorder as defined above.
- ECG: QTc-interval \>450 msec.
- Systolic blood pressure \<100 mmHg
- Bradycardia (Hf \< 50/Min) und Arrhythmias
- Hypokalemia or Hypomagnesemia
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00612079
Start Date
September 1 2007
End Date
November 1 2008
Last Update
September 17 2012
Active Locations (1)
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1
University of Psychiatry Hospital
Zurich, Canton of Zurich, Switzerland, CH-8032