Status:
COMPLETED
GFR Measurement With Contrast-enhanced Dynamic MRI
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Transplantation, Kidney
Graft Occlusion, Vascular
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The aim of the study is to optimize and validate this MR-based GFR measurement in patients with a renal transplant, compared with the reference method, the Cr51- EDTA method: to select the most accura...
Detailed Description
Cr51- EDTA method is considered the reference method for measurement of glomerular filtration rate (GFR). However, this method requires several hours and several blood and urinary samplings. Therefore...
Eligibility Criteria
Inclusion
- Patient with a renal transplant presenting with a graft dysfunction or a suspicion of vascular complication (renal artery stenosis…) or of urinary complication (dilatation of excretory system, collection) justifying to perform a non urgent MR examination
- Calculated glomerular clearance (MDRD method) \> 20 ml/min
- Age ≥ 18 yo at the time of inclusion
- Negative pregnancy test
- Affiliation to the Social Security
- Written informed consent signed
Exclusion
- Contra-indication to MRI: neurovascular clips, pacemaker, cochlear implant, orbital metallic object, claustrophobic patients…
- Contra-indication to gadolinium: previous hypersensitivity to Gd-Chelates
- Pregnancy or breastfeeding women
- Adult under legal supervision
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT00614081
Start Date
January 1 2008
End Date
March 1 2013
Last Update
May 22 2013
Active Locations (1)
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1
Service d'imagerie Diagnostique et interventionelle de l'adulte, Hôpital Pellegrin, CHU de Bordeaux
Bordeaux, France, 33076