Status:
COMPLETED
Structural Neuroplasticity Associated With Aerobic Treadmill Training in Geriatric Chronic Stroke Survivors
Lead Sponsor:
Andreas R Luft
Collaborating Sponsors:
Robert Bosch Medical Center
Max-Planck-Institute Tuebingen
Conditions:
Stroke
Hemiparesis
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Aerobic treadmill exercise has been shown to improve walking, cardiovascular fitness and thereby risk factor profiles in chronic stroke patients (Macko et al., Stroke 2005). The proposed project is a ...
Eligibility Criteria
Inclusion
- women and men aged \> 60 years
- first ever ischemic stroke at least prior 6 months
- all conventional inpatient and outpatient physical therapy completed
- residual hemiparetic gait disturbance adequate language and neurocognitive function to participate in exercise training and testing
Exclusion
- already performing \> 20 minutes aerobic exercise 3 X/ week
- Alcohol consumption \>2 oz liquor, or 2x 4oz glasses of wine, or 2x 12 oz cans of beer per day.
- Cardiac history of
- unstable angina
- recent (\< 3 months) myocardial infarction
- congestive heart failure (NYHA category II)
- hemodynamically significant valvular dysfunction.
- Medical History:
- recent hospitalization (\<3 months) for severe medical disease
- symptomatic peripheral arterial occlusive disease
- orthopedic or chronic pain conditions restricting exercise
- pulmonary or renal failure
- active cancer
- poorly controlled hypertension (\>160/100) or diabetes mellitis (fasting glucose\>180 mg/dl, HbA1C \>10%)
- Neurological history of
- dementia
- receptive or global aphasia that confounds testing and training, operationally defined as unable to follow 2 point commands
- cognitive deficits (other than dementia and aphasia, as above)
- (e) non-stroke neuromuscular disorder restricting exercise (eg Parkinson's Syndrome) (f) untreated major depression
- exclusion criteria for MRI scanning (metal implants (e.g. pacemaker), claustrophobia, etc.)
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT00614224
Start Date
January 1 2008
End Date
April 1 2010
Last Update
May 28 2015
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