Status:
COMPLETED
Differential Risks for Melanoma: p16 and DNA Repair
Lead Sponsor:
Memorial Sloan Kettering Cancer Center
Collaborating Sponsors:
University of New Mexico
Yale University
Conditions:
Melanoma
Skin Melanoma
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others. People respond to the environment in different ways. Some may be born with gen...
Eligibility Criteria
Inclusion
- Cases will be patients 18 years or older with a histologically confirmed, second or multiple primary melanoma. These will be sequentially selected from subjects seen at Memorial Sloan-Kettering Cancer Center or the Yale University Pigmented Lesion Clinic.
- Controls will be patients 18 years or older with a histologically confirmed first primary melanoma diagnosed no earlier than 12 months prior to the study start date. One control will be selected per case. These patients will be referred to the study by the Melanoma Disease Management Team at Memorial Sloan-Kettering Cancer Center. Controls will be frequency-matched to cases on the basis of sex and age (within 10 year age groups).
- Healthy controls will be subjects 18 years or older recruited from the general population through random digit dialing. These subjects will have no history of melanoma. They will also be frequency matched to cases on the basis of sex and 10-year age group.
- The subject must have a histologically confirmed malignant melanoma.
- Cases may have an in situ melanoma as the second primary.
- Melanoma Controls may have only one primary melanoma.
- Healthy controls should have no history of melanoma.
- The subject's physician consents to his/her patient's participation in the study (if the subject has a diagnosis of melanoma).
- The subject has consented, in writing, to participate in the study
Exclusion
- Karnofsky status less than 60 (see Appendix). This will be evaluated by the physician treating the subject for melanoma at the time permission is given for participation
- Patient had chemotherapy or radiation therapy within the last 6 weeks.
Key Trial Info
Start Date :
February 1 1997
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
323 Patients enrolled
Trial Details
Trial ID
NCT00615095
Start Date
February 1 1997
End Date
April 1 2011
Last Update
April 20 2011
Active Locations (1)
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1
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10065