Status:
TERMINATED
Markers of Defective Membrane Remodelling in Scott-like Syndromes
Lead Sponsor:
University Hospital, Strasbourg, France
Collaborating Sponsors:
Louis Pasteur University, Strasbourg
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Unexplained Isolated Provoked Hemorrhages
Familial Bleeding Disorder
Eligibility:
All Genders
2-80 years
Brief Summary
Purpose: Identification of the gene(s) involved in plasma membrane remodelling. Identification of the circulating markers affected by the defective membrane remodelling in a collection of families wit...
Eligibility Criteria
Inclusion
- Patients with unexplained provoked hemorrhages (surgery, tooth extraction, birth …), and associated with reduced prothrombin consomption (residual prothrombine in serum \> à 5%).
- Family members of the patients defined above, with or without unexplained hemorrhages (symptomatic or not).
- Patient's approval based on detailed information given by the pratician
Exclusion
- Patients with primary hemostasis defect or defective blood coagulation factor(s) possibly explaining the bleeding disorder.
- Anémia,
- patients known to be affected by Factor V New York .
- Patients enrolled in a previous clinical study, the exclusion period of which is not yet completed. - Collaboration to the study rejected by the patient
- Patients that are not registered for medical care social insurance.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00617721
Start Date
June 1 2008
Last Update
June 17 2016
Active Locations (5)
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1
Hôpital Antoine Béclère, Service d'Hématologie Biologique
Clamart, France, 92140
2
Laboratoire d'Hémostase et d'Immunologie, Centre Hospitalier
Le Mans, France, 72037
3
Laboratoire d'Hématologie, Hôpital Robert Debré
Reims, France, 51092
4
Laboratoire d'Hématologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg
Strasbourg, France, 67098