Status:
COMPLETED
The Effects of Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat in the Polycystic Ovary Syndrome
Lead Sponsor:
Keogh Institute for Medical Research
Collaborating Sponsors:
Royal Perth Hospital
Conditions:
Polycystic Ovary Syndrome
Eligibility:
FEMALE
18-50 years
Phase:
PHASE4
Brief Summary
We hypothesise that fish oils will have a beneficial effect on cardiometabolic parameters in women with PCOS. The purpose of this study therefore is to examine the effects of fish oils on blood pressu...
Detailed Description
The prevalence of abnormalities of blood pressure (ABP), variability of heart rate (HRV) and liver fat content is increased in women with the polycystic ovary syndrome (PCOS). We hypothesise that fish...
Eligibility Criteria
Inclusion
- Overweight/obese women with PCOS as per 1990 NIH criteria (see below)
- Non-smokers
- Age\>18 years, premenopausal
- Acceptable to have/be on treatment for type 2 diabetes mellitus and/or dyslipidaemia
- Acceptable to be taking the oral contraceptive pill
Exclusion
- Uncontrolled hypertension (BP\>160/100mmHg)
- Known co-morbidities including liver or renal disease
- Already taking fish oil supplements
- Other intercurrent illness (major surgery, CV event)
- Smokers
- Alcohol intake \>20g/day
- Pregnancy
- Any metallic implant (contraindication for MRI).
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2009
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00620529
Start Date
February 1 2008
End Date
February 1 2009
Last Update
February 2 2010
Active Locations (1)
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1
School of Medicine and Pharmacology, Royal Perth Hospital
Perth, Western Australia, Australia, 6000