Status:
COMPLETED
Gene Expression in Obesity and Insulin Resistance
Lead Sponsor:
Marjukka Kolehmainen
Collaborating Sponsors:
University of Eastern Finland
Wageningen University
Conditions:
Insulin Resistance
Metabolic Syndrome
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Lifestyle and genetic factors interact in the development of obesity and the metabolic syndrome. The molecular mechanisms underlying the beneficial dietary modifications are, however, unclear. We aime...
Detailed Description
The objective of the study is to examine the expression of genes and gene regions involved in obesity, insulin resistance and lipid metabolism. We aim to identify new genes which are involved in the d...
Eligibility Criteria
Inclusion
- The subjects had impaired fasting glycemia (fasting plasma glucose concentration 5.6-7.0 mmol/L) or impaired glucose tolerance (2-hour plasma glucose concentration 7.8-11.0 mmol/L)
- AND at least 2 other features of the metabolic syndrome according to the Adult Treatment Panel III criteria as modified by the AHA:
- waist circumference \>102 cm (males)/ \>88 cm (females)
- fasting serum triacylglycerol concentration \>1.7 mmol/L
- fasting serum HDL-cholesterol \<1.0 mmol/L (males) / \<1.3 mmol/L (females)
- blood pressure \>130/80 mmHg.
Exclusion
- liver, kidney and thyroid dysfunction
Key Trial Info
Start Date :
October 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2005
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00621205
Start Date
October 1 2003
End Date
December 1 2005
Last Update
April 17 2012
Active Locations (1)
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1
University of Kuopio, School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre
Kuopio, Finland, FI-70211