Status:
COMPLETED
Risperidone and Olanzapine for the Schizophrenic Patients With Neuroleptic-Induced Tardive Dyskinesia
Lead Sponsor:
Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
Collaborating Sponsors:
Department of Health
Conditions:
Neuroleptic-Induced Tardive Dyskinesia
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
We initiate a study with research grant from department of health and Taoyuan mental hospital and choose risperidone and olanzapine as study medications. We compare the effects of these 2 drugs in sch...
Detailed Description
Objective: First generation antipsychotics would induce tardive dyskinesia in some schizophrenic patients. Second generation antipsychotics were the choices for these patients. But which one of second...
Eligibility Criteria
Inclusion
- Age of 18-70 y/o
- Female patients did not have pregnancy plans and must agree to use reliable pregnancy prevention methods if during childbearing age
- Meet schizophrenia, schizophreniform or schizoaffective disorder criteria of DSM-IV
- Fulfill DSM-IV neuroleptic-induced tardive dyskinesia research criteria, the severity of tardive dyskinesia was no less than moderate degree (\> or =4) assessed by global impression of Extrapyramidal System Rating Scale (item 42 of ESRS)
- Patients or legal responsible people agree to join study and sign informed consent
Exclusion
- Had other axis I diagnosis of DSM-IV
- Unstable major systemic diseases
- Had neurological disorder influenced to EPS assessment
- Substance abuse or dependence other then coffee or tobacco within 6 months before study
Key Trial Info
Start Date :
July 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2004
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00621998
Start Date
July 1 2000
End Date
June 1 2004
Last Update
February 22 2008
Active Locations (1)
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1
Taoyuan Mental Hospital
Taoyuan District, Taiwan, 33058