Status:
COMPLETED
The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery
Lead Sponsor:
Hull University Teaching Hospitals NHS Trust
Collaborating Sponsors:
North of England Medical & Hyperbaric Services
Conditions:
Myocardial Reperfusion Injury
Cytoprotection
Eligibility:
All Genders
20-85 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study was to determine if treating patients who have coronary heart disease with hyperbaric oxygen (HBO) prior to coronary artery bypass graft (CABG) surgery reduces injury to the ...
Eligibility Criteria
Inclusion
- Patients undergoing elective first time CABG
- Patients with at least 1 vessel coronary artery disease undergoing on- pump CABG
Exclusion
- Age ≤ 20 years or ≥ 85 years
- Ejection fraction \< 30%
- Unstable angina
- Recent myocardial infarction (\< 1 month)
- Any additional cardiac disease (e.g. arrythmia, aneurysm, valvular/septal disease, dissection or elevated pulmonary artery pressure)
- Any end stage organ failure (e.g. renal and respiratory failure)
- History of chronic obstructive pulmonary disease (COPD)
- Pneumothorax
- Pulmonary bullae
- Convulsions
- Current history of malignancy
- Severe myopia or intraocular lens
- Patients on K+(ATP) Channel Openers e.g. Nicorandil, Oral Hypoglycemics, Opioid Analgesics, Catecholamines.
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
81 Patients enrolled
Trial Details
Trial ID
NCT00623142
Start Date
January 1 2005
End Date
January 1 2008
Last Update
July 15 2019
Active Locations (1)
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1
Hull & East Yorkshire NHS Trust (Castle Hill Hospital)
Hull, East Riding Of Yorkshire, United Kingdom, HU16 5JQ