Status:
UNKNOWN
Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Conditions:
Hepatic Insufficiency
Liver Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of the study is to determine whether intravenous glucose administration before liver resection preserves hepatic glycogen resulting in improved hepatic metabolic function after the operation....
Detailed Description
Background. With a reported incidence of up to 70%, liver failure is the most frequent complication necessitating intensive care and prolonging hospital stay. Animal studies suggest that the glycogen ...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists class ≤3
- liver resection (one or more liver segments) for primary or secondary malignancy
- ability to give informed consent
Exclusion
- signs of severe malnutrition or obesity: body mass index (BMI) \<20 or \>30 kg.m-2, more than 10% involuntary body weight loss over the preceding six months, serum albumin \<35 g.L-1
- chronic viral liver disease
- diabetes mellitus
- significant cardiorespiratory, renal and neurological disease
- musculoskeletal or neuromuscular disease
- severe anemia (hemoglobin \<10 g.dL-1)
- history of severe sciatica or back surgery or other conditions which contraindicate the use of an epidural catheter
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00623662
Start Date
February 1 2008
End Date
March 1 2019
Last Update
April 3 2018
Active Locations (1)
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1
Royal Victoria Hospital, McGill University Health Centre
Montreal, Quebec, Canada, H3A 1A1