Status:
COMPLETED
Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial
Lead Sponsor:
National Naval Medical Center
Collaborating Sponsors:
Uniformed Services University of the Health Sciences
National Cancer Institute (NCI)
Conditions:
Colorectal Neoplasms
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We hypothesized that aberrant crypt foci (ACF) are precursors of colon cancer; their prevention would correlate with cancer risk and their elimination would reduce that risk. In this study we wished t...
Detailed Description
Subjects are randomly assigned at the time of stain-enhanced magnification colonoscopy to have any ACF removed or merely observed. Subjects are evenly divided into those with and those without a perso...
Eligibility Criteria
Inclusion
- Dept.of Defense Healthcare Beneficiaries
- Age 18 or over, non-pregnant
- History of colorectal cancer or other indication for colonoscopic screening
- At least half of large intestine remaining
- No use of investigational or chemotherapeutic drugs within 6 mos. -
Exclusion
- History suggesting familial colon cancer syndrome
- \< 6 mos since colon resection or since treatment for colon cancer
- Anticipated colon surgery within one year of entry
- Inability to participate in scheduled followup at one year
- Medical or psychiatric condition which would make patient a poor candidate -
Key Trial Info
Start Date :
January 1 1999
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
98 Patients enrolled
Trial Details
Trial ID
NCT00623883
Start Date
January 1 1999
End Date
June 1 2007
Last Update
February 26 2008
Active Locations (1)
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1
National Naval Medical Center
Bethesda, Maryland, United States, 20889