Status:
COMPLETED
Role of Cigarette Smoking in Regulating Allergen-induced Early and Late Responses in Mild Asthmatics
Lead Sponsor:
Hamilton Health Sciences Corporation
Conditions:
Asthma
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
The objective of this study is to determine the effect of cigarette smoking on inflammatory cell recruitment to the lungs after an allergen challenge, in non-smoking and currently smoking mild asthmat...
Detailed Description
10 non-smoking adult subjects and 10 smoking adult subjects with mild atopic asthma will be studied. Part 1: On the first study day of the triad, subjects will undergo screening procedures, including...
Eligibility Criteria
Inclusion
- Subjects with mild atopic asthma, presently well controlled on ß2-agonist only.
- Baseline FEV1 more than or equal to 70% of predicted normal.
Exclusion
- Past or present cardiovascular, renal, liver or endocrine disease.
- Airway infection during the last 4 weeks.
- Exacerbation during the last 4 weeks.
- Inhaled or oral steroids during the last 4 weeks.
- Anti-asthma medication other than inhaled and/or oral ß2-agonists during the last 4 weeks.
- Pregnant or lactating women or women actively seeking pregnancy or lack of adequate contraception.
Key Trial Info
Start Date :
August 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00626171
Start Date
August 1 2008
End Date
July 1 2009
Last Update
April 24 2013
Active Locations (1)
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1
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5