Status:
COMPLETED
The Effects of Walnuts on Antioxidant Capacity and Nutritional Status in Humans
Lead Sponsor:
Tufts University
Collaborating Sponsors:
California Walnut Commission
Tufts Medical Center
Conditions:
Healthy
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The goal of this study is to find out if the daily consumption of English walnuts (Juglans regia L.) for 6 wk, at a dose readily incorporated into the diet (0.75 or 1.50 oz), will have a positive effe...
Detailed Description
Epidemiological studies conducted in large populations have consistently shown that increased consumption of plant-based, antioxidant-rich foods, i.e., fruits, vegetables, grains, and nuts, reduces th...
Eligibility Criteria
Inclusion
- Generally healthy men and postmenopausal women age 50 or over
- BMI 18.5-35 kg/m2
Exclusion
- Cigarette smoking and/or nicotine replacement use
- History or known allergy to nuts of any kind
- Regular consumption of ≥ 5 oz nuts/week for 6 weeks prior to study admission
- Individuals taking estrogen
- Use of cholesterol-lowering medications
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 95 mmHg
- Regular use of oral steroids
- Regular daily intake of ≥ 2 alcoholic drinks
- Illicit drug use
- No fish oil supplements (including cod liver oil) for 6 weeks prior to study admission
- No high dose (≥ 3X RDA) supplements of vitamins C, E, selenium, or beta-carotene for one month prior to study admission
- No dietary supplements containing phenolic compounds, i.e., herbal preparations, or berry containing preparations (such as cranberry capsules) for one month prior to study admission
- No regular consumption of pomegranate juice (≥ 180 mL or 6 oz/d, ≥ 3 times/wk) for one month prior to study admission
Key Trial Info
Start Date :
February 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00626691
Start Date
February 1 2007
End Date
December 1 2007
Last Update
February 19 2009
Active Locations (1)
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1
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, United States, 02111