Status:
COMPLETED
Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Lead Sponsor:
University of Split
Collaborating Sponsors:
Dr Ivancica Pavlicevic Family Practice Office
Conditions:
Hypertension
Eligibility:
All Genders
55-78 years
Phase:
PHASE4
Brief Summary
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.
Detailed Description
To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.
Eligibility Criteria
Inclusion
- Treated hypertensives of either gender aged between 55 and 76 years
- About 50% with concomitant osteoarthritis of the hip or knee
Exclusion
- Normotensive persons or untreated hypertensives
- Individuals outside the age limits
- General exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2006
Estimated Enrollment :
88 Patients enrolled
Trial Details
Trial ID
NCT00631514
Start Date
January 1 2005
End Date
September 1 2006
Last Update
March 10 2008
Active Locations (1)
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1
Split University School of Medicine. Family Practice Department
Split, Croatia, 21000