Status:
COMPLETED
Evaluating the Effects of Supplemental Vitamin C on Infant Lung Function in Pregnant Smoking Women
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Pregnancy
Smoking
Eligibility:
FEMALE
15+ years
Phase:
NA
Brief Summary
Women who smoke during their pregnancy place their unborn child at an increased risk of health problems, including decreased lung function and possible lung diseases later in life. Preliminary animal ...
Detailed Description
Approximately 12% of women smoke during pregnancy, and at least 500,000 babies are born each year having been exposed to nicotine. These infants have poor lung function at birth and have an increased ...
Eligibility Criteria
Inclusion
- Randomly assigned to a study intervention at less than 22 weeks of gestation
- History of smoking
- Singleton gestation pregnancy
- Smoking cessation intervention offered but declined
Exclusion
- Multiple gestation pregnancy
- Documented major fetal congenital anomalies
- History of kidney stones
- Insulin dependent diabetes
- Current participation in other research projects that may interfere with this study
- Continuous use of high dose vitamin C since last menstrual period (LMP) or initial ascorbic acid level greater than 100 micromoles/liter
Key Trial Info
Start Date :
March 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2012
Estimated Enrollment :
282 Patients enrolled
Trial Details
Trial ID
NCT00632476
Start Date
March 1 2007
End Date
July 1 2012
Last Update
September 4 2013
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97266