Status:
TERMINATED
EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye
Lead Sponsor:
University Hospital Freiburg
Collaborating Sponsors:
Boehringer Ingelheim
Conditions:
Retinal Artery Occlusion
Fibrinolysis
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
The aim of the EAGLE Study is to compare the efficacy of conservative medical treatment and local intraarterial fibrinolysis in patients with central retinal artery occlusion and to evaluate benefit a...
Eligibility Criteria
Inclusion
- Subtotal central retinal artery occlusion or central retinal artery occlusion with choroidal hypoperfusion not lasting longer than 20h
- Patients aged from 18 years to 75 years (in case of pre-existing blindness of other eye also older than 75 years)
- Informed consent of the patient
Exclusion
- Central retinal artery occlusion lasting longer than 20h
- Eye diseases, namely branch retinal artery occlusion, cilioretinal arteries supplying the macula, combined arterial-venous occlusion, proliferative diabetic retinopathy and elevated intraocular pressure (over 30 mmHg)
- Systemic diseases, namely severe general diseases, systemic arterial hypertension (systolic pressure \> 200 mmHg), despite medical therapy, acute systemic inflammation (erythrocyte sedimentation rate \> 30 mm within the first hour/ C-reactive protein \> 1,0 mg/dl), antithrombin-III deficiency in case of thrombocytopenia (\< 100000 per ml): pathologic clotting time, acute pancreatitis with elevated pancreas enzymes
- Medical History: heart attack within the last 6 weeks, intracerebral bleeding or neurosurgical operation within the last 4 weeks, therapy with marcumar/warfarin, allergic reaction to contrast agent, haemorrhagic diathesis, aneurysms, inflammatory vascular diseases (e.g., giant cell arteritis, Wegener´s granulomatosis), endocarditis, gastric ulcer
- Patient participation in other studies during the prior 4 weeks
- No willingness and ability of the patient to participate in all follow-up examinations
- Pregnancy
- Written consent not given
- Patient is not mobile (bedridden)
- Other conditions/ circumstances likely to lead to poor treatment adherence (e.g., history of poor compliance, alcohol or drug dependency, no fixed abode)
Key Trial Info
Start Date :
September 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT00637468
Start Date
September 1 2002
Last Update
March 18 2008
Active Locations (21)
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1
Universityhospital Graz
Graz, Austria
2
Universityhospital Innsbruck
Innsbruck, Austria
3
Allgemeines Krankenhaus Wien
Vienna, Austria
4
University Medical Center Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, Germany