Status:
TERMINATED
Insulin Resistance in Nonalcoholic Fatty Liver Disease: A Case Control Study
Lead Sponsor:
Duke University
Collaborating Sponsors:
University of Florida
Conditions:
Insulin Resistance
Nonalcoholic Fatty Liver Disease
Eligibility:
All Genders
18-75 years
Brief Summary
We hypothesize that insulin resistance is characteristic of nonalcoholic fatty liver disease as compared to age, gender, non-diabetic BMI-matched control subjects, both healthy and those with non-cirr...
Detailed Description
Purpose of the study: To date, no case control study evaluating insulin resistance (IR) in nonalcoholic fatty liver disease (NALFD) has been published. We hypothesize that IR is characteristic of NAF...
Eligibility Criteria
Inclusion
- Biochemical and liver histologic features to confirm the presence of a healthy liver, fatty liver, and/or non-fatty liver with inflammation due to another etiology besides NAFLD.
Exclusion
- \> 20 grams of alcohol/day
- Impaired oral glucose tolerance test
- Clinical or histologic evidence of cirrhosis (stage 5-6 fibrosis) or portal hypertension.
- Chronic hepatitis C infection
- Known diabetes mellitus or need for insulin-sensitizing agents and/or insulin therapy.
- Pregnancy
Key Trial Info
Start Date :
July 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 13 2017
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00637520
Start Date
July 1 2007
End Date
April 13 2017
Last Update
July 11 2017
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710