Status:
TERMINATED
Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Dent's Disease
Nephrolithiasis
Eligibility:
MALE
3-18 years
Phase:
PHASE2
PHASE3
Brief Summary
Intrarenal calcifications (nephrocalcinosis) is present in Dent's disease and likely contribute to progression toward renal failure. In order to prevent this complication it is usually proposed to tre...
Detailed Description
Intrarenal calcifications (nephrocalcinosis) is present in Dent's disease and likely contribute to progression toward renal failure. In order to prevent this complication it is usually proposed to tre...
Eligibility Criteria
Inclusion
- Children \> 3 yrs old who met at least three standard criteria for Dent's disease including hypercalciuria, low molecular weight proteinuria and one of the following disorders: nephrocalcinosis, nephrolithiasis, renal failure, aminoaciduria, glucosuria, renal phosphate wasting, or familial history of Dent's disease.
- Dent's Disease confirmed by direct sequencing of the CLCN5 gene according to Lloyd et al.
Exclusion
- Patients presenting hyponatremia (\< 135 mM), hypokalaemia (\< 3.3 mM), severe fanconi syndrome, or chronic renal failure (GFR estimated with the Schwartz formula \< 30 mL.min-1.1.73m-2) were excluded from the study.
- Overt renal loss of sodium
- Inability to adapt to severe sodium restriction
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2005
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00638482
Start Date
July 1 2003
End Date
December 1 2005
Last Update
March 19 2008
Active Locations (1)
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1
Centre d'investigation clinique HOPITAL GEORGE POMPIDOU
Paris, France, 75015