Status:
COMPLETED
A Long-term Moderate Intervention With n-3 LC-PUFA-supplemented Dairy Products in Patients With Rheumatoid Arthritis
Lead Sponsor:
University of Jena
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
35-74 years
Phase:
NA
Brief Summary
The effects of n-3 LC-PUFA-supplemented dairy products on inflammation and immunological parameters, biomarkers of oxidative stress, serum lipids, and disease activity were determined in patients with...
Detailed Description
Recent studies suggest that n-3 LC-PUFA may improve cardiovascular and inflammatory diseases. As a precondition for participating in this study, the subjects were provided information in writing and ...
Eligibility Criteria
Inclusion
- Clear diagnosis of Rheumatoid Arthritis
- Patients receiving nonsteroidal anti-inflammatory drugs (NSAID) or corticosteroids (max. 15 mg/d) or both were eligible if dosage had been stable for at least 4 weeks before day 1 of the study and remained below this limit throughout the study
- Patients on disease-modifying antirheumatic drugs (DMARD) had to be on a constant dosage for at least 8 weeks before and throughout the study
Exclusion
- Subjects with gastrointestinal or metabolic diseases, alcohol abuse, taking dietary supplements (e. g. fish oil capsules), known allergies or foodstuff indigestibility
- patient's request, serious infections, inadequate control of arthritis symptoms (over 50% increase of the number of swollen or tender joints), reinstitution of therapy with DMARD, or if patient compliance with the study protocol was doubtful.
Key Trial Info
Start Date :
September 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2005
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00638950
Start Date
September 1 2004
End Date
May 1 2005
Last Update
September 22 2011
Active Locations (1)
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1
University of Jena, Institute of Nutrition, Department of Nutritional Physiology
Jena, Thuringia, Germany, 07743