Status:
TERMINATED
Study of the Effect of Regional Nerve Blocks on Pain and Inflammation After Video Assisted Thorascopic Lung Surgery
Lead Sponsor:
Memorial Medical Center
Collaborating Sponsors:
Henry M. Jackson Foundation for the Advancement of Military Medicine
U.S. Army Medical Research and Development Command
Conditions:
Pain
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to compare: 1. The degree of systemic postoperative inflammation (cytokine measurement) with the degree of post-operative pain 2. The degree of pain and nausea and 3. The...
Detailed Description
* Enrolled subjects scheduled to undergo video-assisted thorascopic surgery (VATS) will be randomized to receive either paravertebral block or placebo(adhesive bandage applied at the site). * All pati...
Eligibility Criteria
Inclusion
- Age greater than 18
- Planned thoracoscopy with low probability(by surgeon estimate) of conversion to open procedure
Exclusion
- Age less than 18
- Clinical or laboratory evidence of systemic infection
- Current pregnancy as assessed by preoperative urine HCG test
- Serious, uncontrolled, non-malignant illness
- Malignant illness requiring systemic chemotherapy in the last 6 months
- Documented allergy to oxycodone, morphine sulfate or acetaminophen
- Contraindication to peripheral nerve blockade or general anesthesia including:
- patient refusal
- active infection at site of planned block
- documented allergy to any local or general anesthetic medications
- significant coagulopathy( prothrombin time \>15 seconds, INR\>1.5
- pre-existing neuropathy and medical conditions or deformities which would compromise block or anesthetic safety
- Planned pleurodesis
- Current use of high dose inhaled or systemic steroids
- Current use of Amiodarone (Cordarone)
- Morbid obesity (BMI=40kg/m2)
- Patients with clinically significant mental health issues such as psychosis requiring treatment with antipsychotic medications.
- Patients unable to consent
- Patients with active infections requiring antibiotics within one month of registration
- Participation in other clinical trials that may interfere with this study
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00639795
Start Date
March 1 2008
End Date
March 1 2011
Last Update
July 3 2013
Active Locations (1)
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1
Memorial Medical Center
Johnstown, Pennsylvania, United States, 15905