Status:
COMPLETED
Right Ventricular Function in Obstructive Sleep Apnea
Lead Sponsor:
Florence Nightingale Hospital, Istanbul
Conditions:
Sleep Apnea, Obstructive
Eligibility:
All Genders
18-80 years
Brief Summary
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic and pulmonary arterial hypertension and their corr...
Detailed Description
Many risk factors for OSA, such as male gender, obesity, and increasing age are the same as for cardiovascular diseases. This fact makes it more difficult to establish a causal relationship between OS...
Eligibility Criteria
Inclusion
- For OSA patients (group1)
- Apnea Hypopnea Index equal or more than 15
- Epworth sleepiness scale equal or more than 10
- No previous treatment for OSA
Exclusion
- Age \< 18 years
- Known hypertension, or 24-hour mean blood pressure of 135 and/or 85 mmHg or more
- Mean pulmonary artery pressure \> 25 mmHg
- Diabetes mellitus
- Left ventricular ejection fraction \< 60%
- Moderate to severe valvular disease
- Cardiomyopathy
- Renal failure
- Coronary artery disease
- Obstructive or restrictive lung disease demonstrated on pulmonary function test
- Connective-tissue or chronic thromboembolic disease
- Pericardial disease
- Cancer and/or other important comorbidities with an expected survival \< 2 years
- Suboptimal echocardiographic images for measurements
Key Trial Info
Start Date :
June 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT00640536
Start Date
June 1 2006
End Date
June 1 2008
Last Update
December 1 2008
Active Locations (1)
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1
Florence Nightingale Hospital
Istanbul, Caglayan, Turkey (Türkiye), 34381