Status:
COMPLETED
A Study of Avastin (Bevacizumab) in Combination With Standard Chemotherapy in Children and Adolescents With Sarcoma.
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Sarcoma
Eligibility:
All Genders
6-18 years
Phase:
PHASE2
Brief Summary
This open-label two-arm study will assess the safety and efficacy of a combination of bevacizumab + standard chemotherapy with standard chemotherapy alone as active comparator in childhood and adolesc...
Eligibility Criteria
Inclusion
- childhood and adolescent patients aged \>/=6 months to 18 years of age
- metastatic rhabdomyosarcoma or non-rhabdomyosarcoma soft tissue sarcoma
- adequate bone marrow function
- adequate renal and liver function
- adequate blood clotting
Exclusion
- previous malignant tumors
- tumor invading major blood vessels
- prior systemic anti-tumor treatment
Key Trial Info
Start Date :
July 29 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2019
Estimated Enrollment :
154 Patients enrolled
Trial Details
Trial ID
NCT00643565
Start Date
July 29 2008
End Date
April 30 2019
Last Update
October 22 2019
Active Locations (61)
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1
Hôpital Enfants Reine Fabiola
Brussels, Belgium, 1020
2
Cliniques Universitaires St-Luc
Brussels, Belgium, 1200
3
UZ Gent
Ghent, Belgium, 9000
4
Instituto Nacional do Cancer - INCA
Rio de Janeiro, Rio de Janeiro, Brazil, 20560-120