Status:
COMPLETED
Non-Invasive Positive Pressure Ventilation and Adult Respiratory Distress Syndrome (ARDS)
Lead Sponsor:
Eskisehir Osmangazi University
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background and objective: To determine the efficacy of non-invasive positive pressure ventilation (NPPV) and its effects upon intubation rate and mortality in ARDS.
Detailed Description
Methods: This study was performed in the respiratory intensive care unit (ICU) at a university hospital. 20 patients who achieved the diagnostic criteria for ARDS were included. The patients were pros...
Eligibility Criteria
Inclusion
- The following criteria indicated immediate intubation was needed:
- Apne or respiratory pauses with loss of consciousness or gasping for breath or imminent respiratory arrest.
- Inability to increase the patient's PaO2 to more than 40 mmHg and SpO2 to more than 80% with a FiO2\>0.6.
- Inability to increase the patient's pH levels above 7.35, and development of blurred consciousness and confusion (Glasgow Coma Scale \<9) due to respiratory acidosis despite all the support given.
- Instability of the patient's hemodynamic parameters (such as systolic blood pressure \<80 mmHg or heart rate \<50 beats/minute lasting \>1 hour despite fluid resuscitation).
Exclusion
- Contraindications for NPPV include:
- The need for urgent intubation.
- The need for frequent aspiration due to excessive secretions (more frequent than 15 min.).
- Inability of the patient to adapt himself / herself to the device or unwillingness to undergo NPPV.
Key Trial Info
Start Date :
August 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00644930
Start Date
August 1 2003
End Date
December 1 2007
Last Update
March 27 2008
Active Locations (1)
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1
Eskisehir Osmangazi University, Medical Faculty,
Eskişehir, Merkez, Turkey (Türkiye), 26040