Status:
COMPLETED
Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Aarhus University Hospital
Conditions:
Growth Hormone Deficiency
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone...
Eligibility Criteria
Inclusion
- Written informed consent
- Must be of legal age and competent
- Age: \>18 and \<60 years old
- Presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study
Exclusion
- Alcohol consumption \>21 units per week
- Malignant disease
- Pregnancy
- Magnetic implants or material in the body
- Claustrophobia
- BMI \>30
- Heart disease (NYHA \>2)
- Uncontrolled hypertension
- Manifest diabetes mellitus
- Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
- Controls are matched on age, gender and BMI
- Inclusion Criteria:
- Written informed consent
- Must be of legal age and competent
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2009
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00646815
Start Date
March 1 2008
End Date
September 1 2009
Last Update
October 22 2009
Active Locations (2)
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1
Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus, Denmark.
Aarhus, Aarhus, Denmark, 8000
2
Medical Department M, Aarhus University Hospital
Aarhus, Denmark, 8000