Status:
TERMINATED
Oxidative Stress and Endothelial Dysfunction in Obstructive Sleep Apnea
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Obstructive Sleep Apnea Syndrome
Endothelial Dysfunction
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
Patients with sleep apnea syndrome have repeated apneic events that induce periodic hypoxia-reoxygenation, drawing away an overproduction of oxidants. This exaggerated generation of oxidants is associ...
Detailed Description
Subjects will undergo overnight polysomnography in the sleep laboratory (PSG1, D0), which will be immediately preceded and followed by measurements of oxidative stress in exhaled gas and vascular rela...
Eligibility Criteria
Inclusion
- No smoking
- 30-70 years old subjects
- being referred for daytime hyper- somnolence and snoring
- apnea hypopnea index \>=30/hour and desaturation index\>=30/hour
Exclusion
- Chronic lung diseases.
- Exposure to occupational contaminants.
- Active smoking within last 2 years.
- Alcoholism.
- Chronic systemic disease other than OSAS.
- Treatment with vasoactive drugs or antioxidants
- Respiratory infection or vaccination during the 6 weeks preceding the PSG1.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT00646971
Start Date
January 1 2008
End Date
April 1 2010
Last Update
July 12 2010
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Assistance Publique - Hôpitaux de Paris Hôpital Antoine Béclère
Clamart, France, 92141