Status:
COMPLETED
Celecoxib in Treating Patients With Stage I, Stage II, or Stage IIIA Non-Small Cell Lung Cancer
Lead Sponsor:
Vanderbilt-Ingram Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Lung Cancer
Eligibility:
All Genders
Phase:
NA
Brief Summary
RATIONALE: Studying samples of tissue, blood, and urine from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cance...
Detailed Description
OBJECTIVES: * To assess cyclo-oxygenase-2 (COX-2) activity in patients with early-stage non-small cell lung cancer (NSCLC) and correlate the results with serum vascular endothelial growth factor (VEG...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Presumed histological or cytological diagnosis of non-small cell lung cancer
- Diagnosis to be confirmed upon study entry to collect biopsy material for correlative studies
- Stage I-IIIA disease
- PATIENT CHARACTERISTICS:
- ECOG performance status of 0-2
- Serum creatinine ≤ 1.5 mg/dL
- Granulocytes ≥ 1,500/mm\^3
- Platelets ≥ 100,000/mm\^3
- AST ≤ 3 times normal
- Bilirubin ≤ 1.5 mg/dL
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No active unresolved infection
- PRIOR CONCURRENT THERAPY:
- At least 7 days since prior and no concurrent non-steroidal anti-inflammatory agents or other cyclo-oxygenase-2 inhibitors
- At least 7 days since prior parenteral antibiotics
- No prior systemic chemotherapy or radiotherapy
Exclusion
Key Trial Info
Start Date :
December 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT00653250
Start Date
December 1 2000
End Date
January 1 2008
Last Update
May 21 2013
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