Status:
UNKNOWN
Diagnostic and Prognostic Biomarkers in Parkinson Disease
Lead Sponsor:
The Parkinson Study Group
Collaborating Sponsors:
United States Department of Defense
Conditions:
Parkinson Disease
Multiple System Atrophy
Eligibility:
All Genders
18+ years
Brief Summary
The overall goal of PROBE is to evaluate the feasibility and potential utility of three markers (alpha-synuclein, transcriptomic profiles and olfactory function) to determine the risk or prognosis of ...
Detailed Description
PROBE will test three biomarkers in PD subjects and controls to determine their feasibility and potential utility as markers of risk and prognosis for PD. This is a case control study, in which PD sub...
Eligibility Criteria
Inclusion
- Parkinson Disease Inclusion Criteria:
- Subject is participating in PostCEPT and meets UK brain bank criteria for PD
- Willing and able to provide informed consent
- Healthy Control Inclusion Criteria:
- Spouse or non blood relative of the PD subject
- No known current diagnosis or history of a neurological disease
- MMSE score \>27
- Age \>45
- Willing and able to provide informed consent
- Parkinsonism/Disease Control Inclusion Criteria (MSA and PSP)
- A diagnosis of Probable MSA based on Consensus Criteria OR Probable PSP based on NINDS-PSP Criteria
- Willing and able to provide informed consent
- Exclusion Criteria for All Groups:
- Current use (within 7 days prior to Baseline Visit) of anticoagulants (e.g., warfarin or heparin)
- Known bleeding disorder (acquired or inherited)
- Known blood disorder (e.g. leukemia) or a history of anemia with a documented hematocrit \<30
- Known pregnancy
- History of nasal trauma, sinusitis, or other nasal pathology that would interfere with smell testing
Exclusion
Key Trial Info
Start Date :
August 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00653783
Start Date
August 1 2007
Last Update
December 31 2008
Active Locations (1)
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1
Parkinson Study Group
Rochester, New York, United States