Status:
COMPLETED
Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
Lead Sponsor:
Oregon Health and Science University
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Oregon State University
Conditions:
Trifunctional Protein Deficiency
Eligibility:
All Genders
7-40 years
Brief Summary
Several hormones involved in body weight regulation increase the subject's ability to burn fat for energy. The purpose of this study is to investigate how burning fat for energy may affect those hormo...
Detailed Description
A role for mitochondrial fatty acid oxidation in the peripheral signaling cascade of leptin, adiponectin and insulin has recently been proposed from animal studies but has not been investigated in hum...
Eligibility Criteria
Inclusion
- confirmed diagnosis of TFP, LCHAD, CPT2 or VLCAD deficiency
- at least 7 years of age
- willingness to complete overnight admission
- generally healthy
Exclusion
- inclusion in another research project that alters macronutrient intake
- diabetes, thyroid disease or other endocrine dysfunction that alters body composition.
- pregnancy
- anemia
Key Trial Info
Start Date :
April 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2011
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT00654004
Start Date
April 1 2006
End Date
January 1 2011
Last Update
April 22 2013
Active Locations (1)
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1
Oregon Health & Science University
Portland, Oregon, United States, 97239