Status:
COMPLETED
Prevention of Post Operative Bone Loss in Children
Lead Sponsor:
University of New Mexico
Collaborating Sponsors:
Thrasher Research Fund
Conditions:
Osteoporosis
Cerebral Palsy
Eligibility:
All Genders
4-18 years
Phase:
NA
Brief Summary
Hypothesis: one-dose pamidronate will prevent post-operative bone loss in children at risk for low bone density Plan: children with chronic disease such as CP, spina bifida, etc. will be recruited pr...
Detailed Description
Children at risk for post operative bone loss will be studied with preoperative DXA scan of spine and distal femora Preoperative screening with standard labs electrolytes, Ca++, PO4, creatinine, Vit ...
Eligibility Criteria
Inclusion
- chronic condition predisposing to low bone density, such as cerebral palsy, osteogenesis imperfecta
- lower extremity surgery proposed that will require post op nonweightbearing, casted or not, for a minimum of 4 weeks
Exclusion
- creatinine \>1.2
- prior bisphosphonate exposure
- orthopaedic implants in distal femoral precluding DXA scan
- inability to cooperate with DXA scan
Key Trial Info
Start Date :
September 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT00655681
Start Date
September 1 2007
End Date
August 1 2011
Last Update
August 22 2023
Active Locations (1)
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1
University of New Mexico Carrie Tingley Hospital
Albuquerque, New Mexico, United States, 87102