Status:
TERMINATED
Inhaled Corticosteroids Versus Observation for Patients With Decreased Lung Function Status
Lead Sponsor:
M.D. Anderson Cancer Center
Conditions:
Bronchiolitis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical research study is to compare lung function of patients who inhale steroids in the early stages of post-transplant constrictive bronchiolitis (PTCB) to patients who continue w...
Detailed Description
The Study Drug: Fluticasone propionate is designed to stop the inflammatory action of asthma cells in PTCB. Screening Tests: Before you can start treatment on this study, you will have a pulmonary ...
Eligibility Criteria
Inclusion
- Patients \>/=18 years of age.
- Patients must be engrafted and at least 80 days post allogeneic hematopoietic stem cell transplantation.
- New onset airflow obstruction defined as decline of forced expiratory volume in 1 second (FEV1) percent predicted \>/= 15%.
- Total Lung Capacity (TLC) \> 85% to rule out restrictive lung disease.
- Patient must be willing to comply with all study procedures and capable of signing informed consent.
Exclusion
- Patients with active pulmonary infection.
- Patients with known hypersensitivity to corticosteroids
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT00656916
Start Date
March 1 2008
End Date
December 1 2010
Last Update
April 23 2012
Active Locations (1)
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1
UT MD Anderson Cancer Center
Houston, Texas, United States, 77030