Status:
COMPLETED
Efficacy of Pamidronate in the Treatment of Bone Loss Associated With Liver Transplant
Lead Sponsor:
Hospital Clinic of Barcelona
Collaborating Sponsors:
Novartis
Conditions:
Bone Disease, Metabolic
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aims of this study are to prospectively evaluate the efficacy of two intravenous infusions of pamidronate 90 mg, associated with calcium and calcidiol, in the early post-transplant period, on bone...
Detailed Description
Patients diagnosed with chronic advanced liver disease awaiting orthotopic liver transplantation will be eligible to take part in this study. Patients excluded from the study will be those younger th...
Eligibility Criteria
Inclusion
- diagnosed with chronic advanced liver disease awaiting orthotopic liver transplantation
Exclusion
- younger than 18 years
- receiving a multiorgan transplant or retransplant
- previous allergy to bisphosphonates
- Previous treatment with fluoride, estrogens, selective estrogen receptor modulators or bisphosphonates
- therapy with glucocorticoids during the last 6 months before transplantation
- previous history of disorders, other than liver disease, known to affect bone metabolism.
Key Trial Info
Start Date :
December 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2003
Estimated Enrollment :
79 Patients enrolled
Trial Details
Trial ID
NCT00657852
Start Date
December 1 2000
End Date
December 1 2003
Last Update
April 14 2008
Active Locations (1)
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1
Hospital Clinic i Provincial of Barcelona
Barcelona, Barcelona, Spain, 08036