Status:
COMPLETED
Rehabilitation Program for Cognitive Deficits in Ugandan Children After Cerebral Malaria
Lead Sponsor:
Makerere University
Collaborating Sponsors:
Karolinska Institutet
Conditions:
Malaria, Cerebral
Eligibility:
All Genders
5-15 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether computerised cognitive rehabilitation training improves cognition in children who have had cerebral malaria.
Detailed Description
Cerebral malaria affects several children in sub-Saharan Africa leaving some survivors with cognitive problems especially in attention and memory. There are currently no tested interventions for such ...
Eligibility Criteria
Inclusion
- CM group
- aged five to 15 years, presenting with asexual forms of P. falciparum malaria on a peripheral blood smear, unarousable coma (not able to localize a painful stimulus) and no other cause for coma (normal CSF).
- CM group
Exclusion
- history of or present meningitis, encephalitis, prior CM, sickle cell disease (SCD), HIV infection, epilepsy, multiple seizures, developmental delay and history of hospitalization for malnutrition.
- Healthy control group Inclusion Criteria:
- aged five to 15 years with no other illness at present, within two years of the CM child (for CM children aged 5 and 6 years, the HC's age wont go below 5 and for CM children aged 14 and 15, the HC's age wont go above 15 years).
- Healthy control group
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT00658450
Start Date
February 1 2008
End Date
October 1 2010
Last Update
December 6 2012
Active Locations (1)
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1
Mulago hospital Acute Care Unit and the Cerebral Malaria Project
Kampala, Kampala, Uganda, 7051