Status:
UNKNOWN
Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
Lead Sponsor:
University of Pavia
Conditions:
Essential Hypertension
Diabetes Mellitus
Eligibility:
All Genders
40-80 years
Phase:
PHASE3
Brief Summary
The anthypertensive treatment with Losartan may have benefits beyond blood pressure reduction on myocardial structure and function in hypertensive diabetic patients. We will evaluate the effect of los...
Eligibility Criteria
Inclusion
- Gender: 50% Male and 50 % female
- Age: 40-80 years
- Race: caucasian
- Well controlled type II Diabetes : fasting glicemia \< 126 mg/dl in two different determinantion or any non fasting glicemia \> 200 mg/dl; HbA1c \< 7%
- Mild to moderate hypertension (BP\>130/80mmHg; \<160/100mmHg)
- Left ventricular hypertrophy (LVMI \> 131/110 g/m2 in males/females respectively)
Exclusion
- other anthypertensive treatment after wash out period of 2 weeks
- abnormal heart rest function (EF \< 55%).
- valvular heart disease
- congenital heart disease
- heart failure or prior myocardial infarction
- renal disease
- liver disease
- connective tissue disease
- pregnancy or lactation
- sensitivity to the study drugs
- contraindication from an approved label
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2009
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00659451
Start Date
April 1 2008
End Date
April 1 2009
Last Update
April 16 2008
Active Locations (1)
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1
University of Pavia
Pavia, Italy