Status:
COMPLETED
Warfarin After Anterior ST-Elevation Myocardial Infarction
Lead Sponsor:
Hamilton Health Sciences Corporation
Conditions:
Myocardial Infarction
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Following severe heart attacks involving the front wall of the heart (anterior myocardial infarction), patients are at risk of developing blood clots in the main pumping chamber that can cause a strok...
Detailed Description
Rationale: Left ventricular mural thrombus (LVT) remains a common complication after anterior ST-elevation myocardial infarction (STEMI) with a reported incidence ranging from 12- 17%. Previous studi...
Eligibility Criteria
Inclusion
- Anterior STEMI
- An ejection fraction less than 40% as per initial LV angiography or echocardiogram
- Randomization possible within hospital admission if anticoagulated with no interruption \> 24 hours
- Patient able and willing to give informed consent to participate in this trial
Exclusion
- history of intracranial hemorrhage
- history of GI bleed last 6 months
- hemoglobin \< 90 g/L
- platelet count \< 100 x 10exp9/L
- ischemic stroke last 30 days
- intracranial tumor or aneurysm
- significant pericardial effusion
- severe renal failure (creatinine \> 250 mmol/L).
Key Trial Info
Start Date :
November 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00662467
Start Date
November 1 2006
End Date
January 1 2008
Last Update
April 21 2008
Active Locations (1)
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1
Hamilton Health Sciences-Hamilton General Hopsital
Hamilton, Ontario, Canada, L8L 2X2