Status:
COMPLETED
Thiazolidinediones (TZD) Bone Loss and the Effects on Bone Marrow Differentiation and Osteoblast Formation
Lead Sponsor:
Emory University
Conditions:
Osteoporosis
Eligibility:
All Genders
18-80 years
Brief Summary
Thiazolidinediones (TZDs) are a commonly used antidiabetic drugs currently used by over a million patients in the United States. Recent studies have shown that treatment with TZD may increase the risk...
Detailed Description
This study aims to determine if TZDs increase the amount of fat and decrease the number of bone producing cells in the bone marrow. A total of 5 subjects who require surgery for mandible (jaw) fractu...
Eligibility Criteria
Inclusion
- Males or females between the ages of 18 and 80 years undergoing ileac crest bone graft to repair traumatic mandible fracture.
- Patients admitted for elective or emergency surgery or trauma.
Exclusion
- Subjects with history of decompensated diabetes (blood glucose \> 200 mg/dl)
- Critically ill patients with multi-organ failure, relevant hepatic disease or impaired renal function (serum creatinine ≥ 2.0 mg/dl)
- HIV
- Hemolytic anemia and/or hematocrit \< 28%
- Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study
- Pregnancy
Key Trial Info
Start Date :
July 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT00663143
Start Date
July 1 2009
End Date
December 1 2010
Last Update
April 1 2015
Active Locations (3)
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1
Grady Memorial Hospital
Atlanta, Georgia, United States, 30303
2
Emory Crawford Long Hospital
Atlanta, Georgia, United States, 30308
3
Emory University Hospital
Atlanta, Georgia, United States, 30322