Status:
TERMINATED
Impact of Deep Brain Stimulation of Subthalamic Nucleus on the Hepatic Glucose Production in Parkinson's Disease
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Idiopathic Parkinson's Disease
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Parkinson' disease is a neurodegenerative disorder characterised by bradykinesia, rigidity, rest tremor and postural instability. Dopaminergic therapy such as L-Dopa and dopamine agonists usually lead...
Detailed Description
ilot study 8 patients Inclusion visit : * Clinical examination/ Interview on health and medical history * Complete UPDRS * Body composition measured by DEXA * Biologic check up * MMS Protocol : Al...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- Age : 18-70 years
- Patient with an idiopathic Parkinson's disease according to the criteria of the "Parkinson's Disease Society Brain Bank" (Hughes et al., 1992)
- Patient treated with a deep brain stimulation according to the French consensus conference of treatment of Parkinson's disease (Consensus Conference Proceeding, 2000)
- Effect of the stimulation 50%
- Weight gain \>5% (after surgery compared to before surgery)
- MMS\>24/30
- No treatment modification 7 days before the inclusion
- Affiliation to social security
- Agreement of patients
- Exclusion criteria :
- Patient treated with antibiotics, AINS, AIS or other treatment which could interfere with the protocol
- Patients with significant heart, respiratory, psychiatric, metabolic, hepatic, kidney diseases; diabetes, heart deficiency, chronic kidney deficiency, untreated thyroid disease …
- Patients with metabolic and/or biological anomalies
- Pregnant women
- Medical or chirurgical previous history which could interfere with the protocol
- Alcohol (\>30g/day); Tobacco (\>10 cigarettes/day)
- Participation to an other study at the same time
Exclusion
Key Trial Info
Start Date :
April 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2008
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00663312
Start Date
April 1 2008
End Date
June 1 2008
Last Update
October 8 2008
Active Locations (1)
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1
CHU
Clermont-Ferrand, France, 63000