Status:
COMPLETED
Neurologic Morbidity and Disability in Acute Lymphoblastic Leukemia Survivors
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Acute Lymphoblastic Leukemia
Eligibility:
All Genders
6-28 years
Brief Summary
Treatment of acute lymphoblastic leukemia achieves high cure rate, but is potentially neurotoxic. Long-term neurologic morbidity in survivors and its effect on function are inadequately studied. Neu...
Detailed Description
Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignant disease. Survival has improved from 5-10% in the early 1960s to over 80% at present. Historically, the central nervous syst...
Eligibility Criteria
Inclusion
- Childhood ALL survivors treated on institutional protocols at
- Patient will be at least 5-years from ALL diagnosis.
- Patient will be at least one year from completion of cancer therapy.
- Absence of recurrent or secondary cancer for at least one year day of enrollment.
- Between 6-28 years of age at the time of evaluation.
- Patient's or at least one parent's English is proficient enough Questionnaire.
- Parent and the child agree to participate. Consent only from will suffice if \> 18 years of age at the time of assessment.
Exclusion
- Recurrent tumor or development of secondary cancer
- Child or parent refuses to participate
- Co-morbid pre-existing disabling neurologic disease, which in the judgment of the principal investigator may compromise clinical observations.
Key Trial Info
Start Date :
August 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2008
Estimated Enrollment :
165 Patients enrolled
Trial Details
Trial ID
NCT00664131
Start Date
August 1 2005
End Date
October 1 2008
Last Update
September 23 2011
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105