Status:
COMPLETED
Diet, Exercise, Metabolism, and Obesity in Older Women
Lead Sponsor:
Wake Forest University Health Sciences
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Abdominal Obesity
Metabolic Syndrome
Eligibility:
FEMALE
50-70 years
Phase:
NA
Brief Summary
Reductions in fat oxidation and resting metabolic rate (RMR) are associated with normal aging and are accelerated with menopause. As a result, postmenopausal women have an increased risk of abdominal ...
Detailed Description
Design Overview: This study's protocol will last approximately 18 months. Phase 1 involves recruitment and screening followed by baseline research testing (Phase 2). Next, subjects will be randomly a...
Eligibility Criteria
Inclusion
- Currently 50 - 70 years of age (at screening)
- Post-menopausal at least 1 year
- Waist diameter of at least 34"
- Able to attend exercise classes 3 times per week
- BMI between 25 \& 40 kg/m2
- MMSE \> 25
Exclusion
- Exercises regularly (ie- more than twice a week for more than 15 minutes per session)?
- Uncontrolled diabetes mellitus or insulin-controlled diabetes?
- Does not drive and does not have a reliable way to pick up meals once a week
- Cancer in past 5 years except skin cancer
- Unwilling or unable to eat prepared foods (non-compliant during test week)
- Unwilling or unable to record food intake accurately
- Self-reported weight loss or gain \>5% in past 6 months
- Smoking within past year, or use of tobacco or nicotine product
- Coronary artery disease, liver disease, renal disease, or other systemic disorders
- Pulmonary disease
- Current use of thiazide diuretics, beta blockers or steroids
- Current use of more than one anti-hypertensive medication
- Current use of anti-depressants or hormone replacement therapy
- Gross physical impairment
- Blindness or retinopathy
- Triglyceride level \>400 mg/dl
- Anemia (Hct \< 37%)
- Contraindication to exercise by ECG or GXT
Key Trial Info
Start Date :
November 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2008
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT00664729
Start Date
November 1 2002
End Date
November 1 2008
Last Update
August 1 2018
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157