Status:
COMPLETED
Familial Schizophrenia and Spectrum Personality Disorders
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Schizophrenia
Eligibility:
All Genders
16-58 years
Brief Summary
We propose to recruit 150 case families (i.e., families with a schizophrenia proband), 150 control families, and 45 control subjects who exhibit schizophrenia spectrum personality symptoms in the abse...
Detailed Description
Specific aims of the proposed study are: 1. To test the hypothesis that abnormalities in predictive pursuit, antisaccade performance, working memory, visual attention (CPT), sensory gating (PPI and P...
Eligibility Criteria
Inclusion
- All male and female participants must be age 16 and above.
- Case probands will include individuals who meet DSM-IV criteria for schizophrenia or Research Diagnostic Criteria (RDC) for schizoaffective disorder.
- Control probands will include individuals matched with case probands with respect to age, gender, and county of residence who do not meet DSM-IV criteria for schizophrenia or other psychotic disorders.
- Case and control relatives will include all available and age-eligible first-degree relatives of identified case and control probands. Exception to this criterion will occur if we identify a schizophrenia proband family of large pedigree willing to participate, then we will include several generations of relatives (second, third or more degree) for subsequent linkage studies in a subgroup of our sample.
- SSP controls will include individuals recruited from the community who exhibit schizophrenia spectrum personality (SSP) traits in the absence of a personal or family history of psychotic illness.
Exclusion
- Subjects under 16 years of age will be excluded.
- Subjects with serious medical, neuro-ophthalmological or neurological illness (e.g., cancer,seizure disorders,encephalopathy), current substance abuse or extensive history or drug dependence will be excluded, with the exception of subjects participating for clinical interview and blood sample only.
- Subjects with mental retardation will be excluded.
- Control probands and SSP controls who meet DSM-IV criteria for a psychotic illness, or have a family history of psychotic illness will be excluded.
- Schizophrenic patients who are judged to be incompetent to provide voluntary informed consent based on the ESC evaluation
Key Trial Info
Start Date :
July 1 2004
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
539 Patients enrolled
Trial Details
Trial ID
NCT00666146
Start Date
July 1 2004
End Date
January 1 2020
Last Update
May 3 2021
Active Locations (3)
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1
Community Mental Health Centers
Baltimore, Maryland, United States, 21201
2
VA Medical Center
Baltimore, Maryland, United States, 21201
3
University of Maryland, Baltimore
Catonsville, Maryland, United States, 21228