Status:
COMPLETED
Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
Lead Sponsor:
University College, London
Conditions:
Lymphoma
Neurotoxicity
Eligibility:
All Genders
18-30 years
Phase:
PHASE2
Brief Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known which regimen of com...
Detailed Description
OBJECTIVES: Primary * To establish neurotoxicity of OEPA+COPP chemotherapy in young adults. Secondary * To determine response rates in patients treated with this regimen. * To determine disease-fr...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Biopsy proven de-novo classical Hodgkin lymphoma
- Any stage disease
- No nodular lymphocyte-predominant Hodgkin lymphoma
- PATIENT CHARACTERISTICS:
- No known or suspected HIV infection
- No pre-existing neurological disorder
- No serious comorbidity which may prevent administration of study treatment
- No other previous malignancy
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for up to 1 year after completion of study treatment
- Creatinine ≤ 1.5 times upper limit of normal (ULN) unless due to the lymphoma
- ALT/AST ≤ 1.5 times ULN unless due to the lymphoma
- Bilirubin ≤ 2 times ULN unless due to the lymphoma
- PRIOR CONCURRENT THERAPY:
- No prior chemotherapy or radiotherapy
- No prior organ transplant
Exclusion
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT00666484
Start Date
March 1 2008
End Date
September 1 2012
Last Update
December 4 2014
Active Locations (5)
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1
Leeds Cancer Centre at St. James's University Hospital
Leeds, England, United Kingdom, LS9 7TF
2
University College Hospital - London
London, England, United Kingdom, NW1 2PG
3
King's College Hospital
London, England, United Kingdom, SE5 9RS
4
Northern Centre for Cancer Treatment at Newcastle General Hospital
Newcastle upon Tyne, England, United Kingdom, NE4 6BE