Status:
ACTIVE_NOT_RECRUITING
Aging, Lifestyle and Inflammation in Veterans Exercising
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
US Department of Veterans Affairs
Conditions:
Inflammation
Aging
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Over half of adults in this country are overweight. This increases risk for heart and blood pressure problems, cancer, stroke and arthritis. While it is difficult to lose large amounts of weight and k...
Detailed Description
Adipose tissue is increasingly recognized as more than an inert depot serving not only to accept and store excess energy in the form of triglycerides, but also to secrete hormones and adipokines that ...
Eligibility Criteria
Inclusion
- BMI 20-40 kg/m2
- Waist 80-120cm (men), 70-110cm (women)
- Stable Medical Regimen \> or = 30 days
- All women over the age of 50 must be postmenopausal for at least 1 year, have serum FSH \>30 mIU/ml, and agree to remain off hormone replacement therapy for the duration of the study
Exclusion
- Pregnancy or Nursing Mothers
- Cigarette Smoking
- Diabetes on Medication or Fasting Glucose \>126 mg/dl
- Poorly controlled hypertension requiring \>3 drugs or beta blockers
- Hyperlipidemia with TG\>400mg/dl, LDL\>190mg/dl or on Lipitor or Crestor
- Other medications affecting glucose, lipid or cytokine levels
- Thyroid Disease
- Weight gain/loss \>5kg in preceding 3 months
- Alcohol \>3oz/day
- Caffeine \>120 oz/day
- Chronic liver, renal or hematological disease
- Lung disease requiring oxygen
- Active cancer on radiation or chemotherapy treatment
- HIV (+) or other disease prone to malnutrition
- Sickle cell anemia
- Active psychosis or dementia
- Chronic untreated depression
- Hemiparetic Stroke
- Coronary Artery or cerebrovascular disease precluding exercise
- Implantable defibrillator
- Other medical condition precluding exercise testing or participation in exercise and weight loss programs, as per medical judgement of study team
Key Trial Info
Start Date :
July 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00667030
Start Date
July 1 2005
End Date
December 1 2025
Last Update
January 23 2025
Active Locations (1)
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1
University of Maryland; Baltimore VA Medical Center
Baltimore, Maryland, United States, 21044