Status:
COMPLETED
A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Osteosarcoma
Malignant Fibrous Histiocytoma (MFH) of Bone
Eligibility:
All Genders
Up to 30 years
Phase:
PHASE2
Brief Summary
This study adopts a novel strategy for first-line treatment of osteosarcoma by combining chemotherapy with anti-angiogenic therapy using bevacizumab (Avastin®), a humanized monoclonal antibody against...
Detailed Description
This is a comprehensive study that uses a novel agent that targets angiogenesis (bevacizumab) in combination with conventional chemotherapy for the treatment of osteosarcoma. Bevacizumab, a monoclonal...
Eligibility Criteria
Inclusion
- Patient must have newly diagnosed high-grade, biopsy proven, osteosarcoma or malignant fibrous histiocytoma (MFH) of bone with no history of prior chemotherapy or radiation;
- Participant is able to perform tasks and daily activities as defined in the study guidelines
- Patient meets established guidelines for adequate function of the kidney, liver, heart and bone marrow
- Participants meets other requirements defined in the eligibility portion of the study
Exclusion
- recent major surgical procedure or injury
- Known bleeding diathesis, platelet disorder or coagulopathy
- Thrombosis
- Cardiac disease or hypertension
- Significant proteinuria
- Central nervous system disease
- Gastrointestinal perforation/abdominal fistula
- Osteosarcoma or MFH of bone as second malignancy
Key Trial Info
Start Date :
June 3 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT00667342
Start Date
June 3 2008
End Date
August 1 2017
Last Update
August 7 2023
Active Locations (5)
Enter a location and click search to find clinical trials sorted by distance.
1
Rady Children's Hospital and Health Center
San Diego, California, United States, 92123
2
Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, United States, 21231
3
NCI/NIH - Pediatric Oncology Branch
Bethesda, Maryland, United States, 20892
4
St Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105