Status:
TERMINATED
Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
Doris Duke Charitable Foundation
Conditions:
Carotid Stenosis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.
Eligibility Criteria
Inclusion
- Subjects with \>= 70% carotid stenosis (unilateral or bilateral) who are scheduled to undergo elective carotid endarterectomy
- Age \>= 18 years
- Agreement of the operating surgeon for patient to participate
Exclusion
- Surgery scheduled \< 14 days after randomization
- Pregnancy
- ALT, GGT \> 3x upper limit of normal (ULN)
- Creatinine \> 3.5 mg/dL
- Prior intolerance to statins
- Reluctance to add or change dosage of statin therapy during study
Key Trial Info
Start Date :
March 13 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 20 2011
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT00670202
Start Date
March 13 2008
End Date
January 20 2011
Last Update
March 29 2017
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115