Status:
COMPLETED
Bevacizumab in Combination With Vinorelbine and Trastuzumab for HER2-Positive, Metastatic Breast Cancer
Lead Sponsor:
Harold J. Burstein, MD, PhD
Collaborating Sponsors:
Brigham and Women's Hospital
Beth Israel Deaconess Medical Center
Conditions:
Breast Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this research study is to determine the effects of the combination of bevacizumab, vinorelbine, and trastuzumab on participants and their cancer.
Detailed Description
* Participants will receive bevacizumab intravenously every 2 weeks. They will also receive trastuzumab and vinorelbine intravenously once a week. Therefore, treatments will alternate between receivin...
Eligibility Criteria
Inclusion
- Histologically or cytologically confirmed invasive breast cancer, with metastatic disease.
- HER2-positive tumor
- Measurable disease defined as at least one lesion that can be accurately measured in at least one dimension as 20mm or greater with conventional techniques or as 10mm or greater with spiral CT scan
- 18 years of age or older
- Life expectancy of more than 12 weeks
- ECOG Performance Status of 0 or 1
- Normal organ and marrow function as outlined in the protocol
- Left ventricular ejection fraction 50% or greater as determined by RVG or echocardiogram within 30 days prior to initiation of protocol therapy
- Patients with stable or previously treated CNS metastases are eligible for study participation, provided there is no history of clinically significant CNS bleeding
- Men and women of child-bearing potential must agree to use adequate contraception prior to study entry and for the duration of study participation
- COHORT A:
- No prior chemotherapy for treatment of metastatic breast cancer
- May NOT have received prior treatment with trastuzumab for recurrent or metastatic breast cancer
- No prior vinorelbine for treatment of breast cancer
- No prior bevacizumab for treatment of breast cancer
- May have received prior radiation therapy and/or any number of lines of hormonal therapy
- Prior trastuzumab therapy in the adjuvant setting is also allowed, providing that relapse occured at least 12 months following the last dose
- Must have recovered from all reversible toxicities related to prior therapy and may not have any pre-existing treatment-related toxicities in excess of Grade 1. Patients must have stopped prior radiation therapy at least 7 days prior to beginning protocol treatment
- COHORT B:
- One prior line of chemotherapy for treatment of metastatic breast cancer or recurrence of breast cancer within 12 months of completion of adjuvant trastuzumab
- No prior vinorelbine for treatment of breast cancer
- No prior bevacizumab for treatment of breast cancer
- May have received prior radiation therapy and/or any number of lines of hormonal therapy
- Must have recovered from all reversible toxicities related to prior therapy and may not have any pre-existing treatment-related toxicities in excess of Grade 1. Patients must have stopped prior radiation therapy at least 7 days prior to beginning protocol treatment
Exclusion
- Patients who have had chemotherapy within 14 days prior to entering the study, ot those who have not recovered adequately from adverse events due to agents administered earlier
- Concurrent radiation therapy
- History of Grade 3 or 4 allergic reactions attributed to compounds of similar chemical or biologic composition as the agents used in this study
- Prior therapy with bevacizumab or vinorelbine
- Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study other than a Genentech-sponsored bevacizumab cancer study
- Inadequately controlled hypertension
- Prior history of hypertensive crisis of hypertensive encephalopathy
- NHYA Grade II or greater congestive heart failure
- History of myocardial infarction of unstable angina within 6 months prior to study enrollment
- History of stroke or transient ischemic attack within 6 months prior to study enrollment
- Progressive or untreated CNS metastases
- Significant vascular disease within 6 months prior to study enrollment
- Symptomatic peripheral vascular disease
- Evidence of bleeding diathesis or coagulopathy
- Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment or anticipation of need for major surgical procedure during the course of the study
- Core biopsy or other minor surgical procedure, excluding placement of vascular access device, within 7 days prior to study enrollment
- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to study enrollment
- Serious non-healing wound, active ulcer, or untreated bone fracture
- Proteinuria at screening
- Pregnant or lactating
- Current and ongoing treatment with full-dose warfarin or its equivalent
Key Trial Info
Start Date :
May 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT00670982
Start Date
May 1 2008
End Date
December 1 2012
Last Update
May 13 2013
Active Locations (7)
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1
Hartford Hospital
Hartford, Connecticut, United States, 06101
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
3
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02115
4
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115