Status:
COMPLETED
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase 1
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Collaborating Sponsors:
Sandler Program for Asthma Research
Conditions:
Healthy
Asthma
Eligibility:
All Genders
18-40 years
Brief Summary
The purpose of the study is to determine the role of nitric oxide (NO) in asthma. We determine the effect of promoter polymorphisms in the gene for the NO producing enzyme, nitric oxide synthase (NOS2...
Detailed Description
The purpose of the study is to determine the role of nitric oxide (NO) in asthma. We determine the effect of promoter polymorphisms in the gene for the NO producing enzyme, nitric oxide synthase (NOS2...
Eligibility Criteria
Inclusion
- Willing/able to give informed consent
- self declared non-atopic, non-asthmatic
- never cigarette smoker,
- no significant occupational exposure to respiratory irritants or toxins,
- no chronic illness
- no chronic use of medications (excluding contraceptive medication),
- no historical unstable cardiac or severe lung disease,
- within study age parameters of 18 - 40
Exclusion
- occupational exposure to hay or grain
- smoked 20 or more packs of cigarettes in a lifetime.
- prior allergen immunotherapy
- Allergy and or asthma
- Students or employees under direct supervision by protocol investigators are ineligible
- Nursing mothers
- pregnancy
- Other investigational medication within the last 30 days
- Other medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
Key Trial Info
Start Date :
May 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2008
Estimated Enrollment :
420 Patients enrolled
Trial Details
Trial ID
NCT00671229
Start Date
May 1 2003
End Date
June 1 2008
Last Update
April 14 2015
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710